Migraine in multiple sclerosis and other chronic inflammatory diseases

Migraine is a very prevalent disease worldwide and major cause of disability. As known for long time, migraine associated with neurogenic inflammation. Epidemiological studies have shown that comorbid several chronic inflammatory diseases, including multiple sclerosis (MS), rheumatic diseases (CIRDs) bowel (IBDs). This brief narrative review highlights some recent data supporting link between these three diseases. Studies found prevalence approximately two-fold higher in compared to the general population. The causal has not been identified yet. Here, we suggest systemic mediators (such as cytokines) gut microbiome make worse or add significant risks. Systemic inflammation biomarkers modification are certainly avenues worth exploring.